The world primary dropped the primary two units, then comfortably levelled earlier than the 19-year-old Italian retired within the remaining set.
Djokovic’s 6-7 (7/9), 6-7 (2/7), 6-1, 6-0, 4-0 win arrange a last-eight conflict with Matteo Berrettini, one other Italian, who progressed after Roger Federer’s withdrawal.
Djokovic, the 2016 champion and chasing a nineteenth main, was dealing with his earliest exit in Paris since 2009 when 19-year-old Musetti stormed by way of the primary two units, hitting blistering winners and discovering the acutest of angles.
However the 76th-ranked Italian, making his Grand Slam debut, then went dramatically off the boil.
The place the primary two units had taken 75 and 66 minutes, Djokovic swept the third in 24 minutes and the fourth in simply 17.
Musetti received solely 14 factors within the third and fourth units earlier than leaving the courtroom for a medical time-out.
Djokovic broke for 1-0 within the decider, injuring a finger as he smashed a winner whereas shedding his stability and falling into the clay.
Musetti gamely fought on however after being damaged twice once more, he known as it quits.